Cloxacilline [INN-French]
Brand names,
Cloxacilline [INN-French]
Analogs
Cloxacilline [INN-French]
Brand Names Mixture
Cloxacilline [INN-French]
Chemical_Formula
C19H18ClN3O5S
Cloxacilline [INN-French]
RX_link
No information avaliable
Cloxacilline [INN-French]
fda sheet
Cloxacilline [INN-French]
msds (material safety sheet)
Cloxacilline [INN-French]
Synthesis Reference
No information avaliable
Cloxacilline [INN-French]
Molecular Weight
435.882 g/mol
Cloxacilline [INN-French]
Melting Point
No information avaliable
Cloxacilline [INN-French]
H2O Solubility
13.9 mg/L
Cloxacilline [INN-French]
State
Solid
Cloxacilline [INN-French]
LogP
2.274
Cloxacilline [INN-French]
Dosage Forms
Capsules (250 mg, 500 mg); Powder (125 mg/5 mL when reconstituted)
Cloxacilline [INN-French]
Indication
Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
Cloxacilline [INN-French]
Pharmacology
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase.
Cloxacilline [INN-French]
Absorption
Well absorbed from the gastrointestinal tract.
Cloxacilline [INN-French]
side effects and Toxicity
Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
Cloxacilline [INN-French]
Patient Information
Cloxacilline [INN-French]
Organisms Affected
Enteric bacteria and other eubacteria